组会讲课人员:林珊珊
Emerging photothermal-derived multimodal synergistic therapy in combating bacterial
Infections
新兴的光热衍生多模式协同治疗对抗细菌感染
主讲人:林珊珊
Chemical Society Reviews | 2021| Issue 15, Volume 50| 8762-8789 | DOI: 10.1039/D1CS00074H
Abstract:
Due to the emerging bacterial resistance and the protection of tenacious biofilms, it is hard for the single antibacterial modality to achieve satisfactory therapeutic effects nowadays. In recent years, photothermal therapy (PTT)-derived multimodal synergistic treatments have received wide attention and exhibited cooperatively enhanced bactericidal activity. PTT features spatiotemporally controllable generation of hyperthermia that could eradicate bacteria without inducing resistance. The synergy of it with other treatments, such as chemotherapy, photo-dynamic/catalytic therapy (PDT/PCT), immunotherapy, and sonodynamic therapy (SDT), could lower the introduced laser density in PTT and avoid undesired overheating injury of normal tissues. Simultaneously, by heat-induced improvement of the bacterial membrane permeability, PTT is conducive for accelerated intracellular permeation of chemotherapeutic drugs as well as reactive oxygen species (ROS) generated by photosensitizers/sonosensitizers, and could promote infiltration of immune cells. Thereby, it could solve the currently existing sterilization deficiencies of other combined therapeutic modes, for example, bacterial resistance for chemotherapy, low drug permeability for PDT/PCT/SDT, adverse immunoreactions for immunotherapy, etc. Admittedly, PTT-derived synergistic treatments are becoming essential in fighting bacterial infection, especially those caused by antibiotic-resistant strains. This review firstly presents the classical and newly reported photothermal agents (PTAs) in brief. Profoundly, through the introduction of delicately designed nanocomposite platforms, we systematically discuss the versatile photothermal-derived multimodal synergistic therapy with the purpose of sterilization application. At the end, challenges to PTT-derived combinational therapy are presented and promising synergistic bactericidal prospects are anticipated.
摘要:
由于细菌耐药性的出现和顽强生物膜的保护,单一的抗菌方式很难取得满意的治疗效果。近年来,光热疗法(PTT)衍生的多模态协同处理受到了广泛关注,表现出协同增强杀菌活性。PTT具有时空可控的热疗产生,可以在不诱导耐药性的情况下消灭细菌。与其他治疗方法如化疗、光动力/催化治疗(PDT/PCT)、免疫治疗、声动力治疗(SDT)协同,可以降低PTT中引入的激光密度,避免正常组织不希望的过热损伤。同时,通过热诱导细菌膜通透性的提高,PTT有利于加速化疗药物的细胞内渗透以及光敏剂/声敏剂产生的活性氧(ROS),促进免疫细胞的浸润。从而可以解决目前其他联合治疗模式存在的灭菌缺陷,如化疗时细菌耐药、PDT/PCT/SDT药物渗透性低、免疫治疗时免疫反应不良等。诚然,PTT衍生的协同治疗在对抗细菌感染方面越来越重要,尤其是那些由耐抗生素菌株引起的感染。本文首先对经典光热剂和最新报道的光热剂作了简要介绍。通过对精细设计的纳米复合平台的介绍,系统地讨论了多功能光热衍生的多模态协同治疗,以杀菌应用为目的。最后,对PTT衍生的联合治疗提出了挑战,并展望了其协同杀菌的前景。